DETAILED NOTES ON LINK ALTERNATIF NAGA26

While in the crystal structure from the D273N mutant of NagA, the side chain of His-143 is 3.0 Å faraway from the phosphonate oxygen in the mimic of your tetrahedral intermediate (21). This end result indicates this group could facilitate the activation of the carbonyl group on the substrate at the side of an interaction With all the metal ion ce